Nerandomilast (Jascayd) is a new oral medication used to treat adults with idiopathic pulmonary fibrosis (IPF). The US Food and Drug Administration (FDA) approved nerandomilast in 2025. It is the first new treatment for IPF in more than a decade. condition that causes scarring of the lungs. The damage worsens over time and makes breathing difficult. As IPF progresses, it becomes difficult to breathe, even at rest.e60dc2a1-f33c-4a05-9b50-8e3e8e597629067b5692-5e0d-45eb-b174-9af21579168c Nerandomilast belongs to a class of medications called phosphodiesterase 4B (PDE4B). inhibitors. Helps slow the decline in lung function in IPF. This can help people with IPF feel better for longer.e60dc2a1-f33c-4a05-9b50-8e3e8e597629c79ef89a-1b64-4133-ac43-e50564d91a01 How does Nerandomilast work? Function Nerandomilast acts by blocking the PDE4B enzyme. When PDE4B is overactive, it can cause inflammation and tissue damage. Targeting the PDE4B enzyme helps slow lung healing.e60dc2a1-f33c-4a05-9b50-8e3e8e5976296912363e-afd5-4627-aca8-e20adc23def4 In clinical trials, people taking nerandomilast experienced a slower decrease in lung function than those who took a placebo. tablet. That means the medication kept his lungs working better over time. Although it does not cure IPF, nerandomilast can slow its progression.e60dc2a1-f33c-4a05-9b50-8e3e8e5976291e9d8cbd-47a6-42e9-bf4c-ed29548ef050 What are the possible side effects of nerandomilast? Side effects Like most medicines, nerandomilast can cause side effects. The most common problems reported are:e60dc2a1-f33c-4a05-9b50-8e3e8e597629ffe6e5ee-97b1-40d6-93fb-538a5899d028 Diarrhea Weight loss Headache COVID-19 Lack of appetite Vomiting Nausea Upper respiratory tract infection Back pain Fatigue Dizziness Depression Are there any? Risks related to nerandomilast? Risks In clinical trials, nerandomilast was safe and well tolerated.e60dc2a1-f33c-4a05-9b50-8e3e8e597629154693c3-2a98-48e3-9293-3d69c5d8dac0 Before taking nerandomilast, tell your doctor about all medical conditions that have, especially any kidney disease or liver problems. Also, tell your healthcare provider if you: Are pregnant Plan to become pregnant Are breastfeeding Plan to breast-feed It is not known whether nerandomilast can harm an unborn baby or pass into breast milk. Some data suggest the drug could cause miscarriage. Nerandomilast is intended for adults. Doctors don’t know if it is safe or effective in children. This medicine may affect the way other medicines work. Tell your healthcare provider about all prescription, over-the-counter, recreational (including illegal), herbal, nutritional, or dietary medications you are taking while using nerandomilast. Your doctor may need to adjust your dose if you also take medications called CYP3A inhibitors or CYP3A inducers. If you take too much nerandomilast, call your doctor or poison control center at 800-222-1222, or go to the nearest emergency room right away. Nerandomilast? How to take Nerandomilast comes in tablet form to take by mouth. You can take this medication with or without food. If you cannot swallow the tablet, you can mix it with water to drink. Carefully follow the instructions on your package label. The recommended dose is 18 milligrams (mg) approximately every 12 hours. Your doctor may reduce your dose if you experience side effects. If you miss a dose of nerandomilast, skip it and take the next dose at the scheduled time. Do not double doses.e60dc2a1-f33c-4a05-9b50-8e3e8e5976294e14020c-58aa-47ad-b0bc-9c4e7058e3e0 Nerandomilast takeaway is the first new treatment approved for IPF in more than 10 years. The medication does not cure IPF, but it can slow its progression. Generally, nerandomilast causes mild side effects, with diarrhea being the most common. Always talk to your healthcare provider about all medications you are taking.
What is Nerandomilast (Jascayd)?
